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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
14.85
Human Site:
S264
Identified Species:
32.67
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
S264
N
S
E
D
S
P
G
S
C
E
I
L
Y
F
N
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
S264
N
S
E
D
S
P
G
S
C
E
I
L
Y
F
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
S264
S
S
E
D
S
S
G
S
C
E
V
L
Y
F
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
S264
S
G
E
P
S
P
G
S
C
D
I
L
H
F
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
C224
S
S
E
D
S
P
G
C
G
E
V
L
Y
F
N
Chicken
Gallus gallus
XP_421203
1656
188583
N275
N
N
E
E
S
P
G
N
Y
E
V
L
N
F
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
R186
C
V
L
F
C
S
C
R
R
D
T
Y
N
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
K301
V
K
Q
L
S
G
G
K
K
D
H
V
T
V
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
T245
N
P
K
P
I
K
L
T
S
D
I
F
S
F
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
73.3
N.A.
60
N.A.
N.A.
73.3
53.3
N.A.
0
N.A.
N.A.
0
N.A.
13.3
P-Site Similarity:
100
100
N.A.
93.3
N.A.
86.6
N.A.
N.A.
86.6
86.6
N.A.
13.3
N.A.
N.A.
0
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
10
0
0
0
10
0
10
10
37
0
0
0
0
0
0
% C
% Asp:
0
0
0
37
0
0
0
0
0
37
0
0
0
0
10
% D
% Glu:
0
0
55
10
0
0
0
0
0
46
0
0
0
10
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
10
0
64
0
% F
% Gly:
0
10
0
0
0
10
64
0
10
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
37
0
0
0
10
% I
% Lys:
0
10
10
0
0
10
0
10
10
0
0
0
0
0
0
% K
% Leu:
0
0
10
10
0
0
10
0
0
0
0
55
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
37
10
0
0
0
0
0
10
0
0
0
0
19
0
28
% N
% Pro:
0
10
0
19
0
46
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% R
% Ser:
28
37
0
0
64
19
0
37
10
0
0
0
10
0
37
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
10
0
10
0
0
% T
% Val:
10
10
0
0
0
0
0
0
0
0
28
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
10
37
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _